Response to muscle inactivity

Across TCGA cell cohorts, RNA activity of the Response to muscle inactivity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGIX, SLC39A4, and ROBO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAGIX grouped by Response to muscle inactivity-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAGIX →	+1.190	+1.229	.002	<.001	3	5
SOFT_TISSUE	SLC39A4 →	+2.195	+1.266	.007	.008	2	5
LUNG_NSCLC_LUSC	ROBO3 →	-2.050	-1.424	.005	.003	3	4
BREAST	TJP3 →	+2.640	+1.081	<.001	.002	3	4
BREAST	HMGN4 →	-1.033	-0.959	<.001	<.001	3	4
BREAST	LRRC26 →	+1.749	+0.700	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAGIX by Response to muscle inactivity activity — BREAST

Explore this box plot interactively →