Response to muscle inactivity

Across TCGA cell cohorts, RNA activity of the Response to muscle inactivity pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WIPI1, SLC12A1, and SPSB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WIPI1 grouped by Response to muscle inactivity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WIPI1 →	+0.161	+1.465	.008	<.001	3	2
SKIN	SLC12A1 →	-0.210	-1.455	.003	.001	3	2
SKIN	SPSB1 →	-0.246	-1.615	.007	.005	3	2
SKIN	NAA10 →	-0.553	-1.479	<.001	.006	3	2
SKIN	KMT2A →	-0.263	-1.546	.007	.001	3	2
SKIN	CCDC90B →	+0.246	+1.455	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WIPI1 by Response to muscle inactivity activity — SKIN

Explore this box plot interactively →