Response to muscle inactivity

Across TCGA cell cohorts, RNA activity of the Response to muscle inactivity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP11, PLAT, and FGFRL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle inactivity activity versus TRIP11 in SKIN (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRIP11 →	+0.905	+1.395	.001	.001	3	2
SKIN	PLAT →	+2.465	+1.395	.003	.001	3	2
SKIN	FGFRL1 →	+2.446	+1.806	.008	.002	3	2
SKIN	CALCOCO1 →	+0.870	+1.351	.007	.003	3	2
SKIN	RANBP6 →	+0.677	+1.395	<.001	.001	3	2
SKIN	TAPBPL →	+2.033	+1.879	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014870 vs TRIP11 — SKIN

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