Skeletal myofibril assembly

Across TCGA cell cohorts, RNA activity of the Skeletal myofibril assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR, ACTL8, and BPIFC, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFLAR grouped by Skeletal myofibril assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CFLAR →	-0.574	-1.440	<.001	<.001	3	10
BONE	ACTL8 →	-0.420	-1.929	<.001	<.001	3	7
STOMACH	BPIFC →	-0.143	-1.298	.002	.009	3	4
BLOOD_Leukemia	ALYREF →	-0.365	-1.161	<.001	.002	3	4
LUNG_SCLC	USP1 →	+0.217	+1.540	<.001	<.001	3	4
LUNG_SCLC	RPLP0 →	+0.307	+1.312	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFLAR by Skeletal myofibril assembly activity — KIDNEY

Explore this box plot interactively →