Skeletal myofibril assembly

Across TCGA cell cohorts, RNA activity of the Skeletal myofibril assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1E, DALRD3, and YTHDC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1E grouped by Skeletal myofibril assembly-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPM1E →	-0.742	-0.833	<.001	<.001	3	4
BREAST	DALRD3 →	-0.742	-0.809	.009	.001	3	4
LUNG_NSCLC_LUAD	YTHDC2 →	-0.493	-0.796	.002	.007	3	4
LUNG_NSCLC_LUSC	RIN1 →	+1.506	+0.320	.007	.004	3	3
STOMACH	IFIH1 →	+2.236	+1.312	.002	.005	3	3
STOMACH	EPHA2 →	+2.161	+1.192	.008	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1E by Skeletal myofibril assembly activity — SKIN

Explore this box plot interactively →