Skeletal myofibril assembly

Across TCGA cell cohorts, RNA activity of the Skeletal myofibril assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTR, OGG1, and KDELR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTR grouped by Skeletal myofibril assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TTR →	-0.194	-0.153	.002	.005	3	5
LIVER	OGG1 →	-0.260	-0.414	.009	<.001	3	5
CNS	KDELR1 →	-0.147	-0.171	<.001	.008	3	5
BREAST	ANLN →	+0.358	+0.288	.002	<.001	3	5
BREAST	PPP3R2 →	+0.170	+0.196	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MYBL2 →	-0.439	-0.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTR by Skeletal myofibril assembly activity — BREAST

Explore this box plot interactively →