Skeletal myofibril assembly

Across TCGA cell cohorts, RNA activity of the Skeletal myofibril assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR, RRAS, and CAPN2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal myofibril assembly activity versus CFLAR in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CFLAR →	+1.718	+0.325	.001	<.001	3	19
LUNG_NSCLC_LUSC	RRAS →	+3.181	+0.359	<.001	<.001	3	16
BLOOD_Lymphoma	CAPN2 →	+2.809	+0.220	<.001	<.001	3	16
BLOOD_Lymphoma	PLEC →	+1.940	+0.307	<.001	<.001	3	16
LUNG_NSCLC_LUSC	AHNAK →	+3.524	+0.338	.001	.002	3	16
LUNG_NSCLC_LUSC	PLAU →	+4.540	+0.306	.001	.005	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014866 vs CFLAR — STOMACH

Explore this scatter interactively →