Skeletal muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD9_S566, SFXN1, and SLC30A9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle cell proliferation activity versus BRD9_S566 in BRCA (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BRD9_S566 →	-0.829	-0.042	<.001	<.001	3	4
BRCA	SFXN1 →	-0.366	-0.051	<.001	<.001	3	4
BRCA	SLC30A9 →	-0.489	-0.040	<.001	<.001	3	4
BRCA	UQCC1 →	-0.441	-0.044	<.001	<.001	3	4
BRCA	FTO_T4 →	-1.326	-0.041	<.001	.003	3	4
HNSC	CEP76_S83 →	+0.421	+0.083	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014856 vs BRD9_S566 — BRCA

Explore this scatter interactively →