Skeletal muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WBP11P3, RANP2, and ZNF33BP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle cell proliferation activity versus WBP11P3 in OV (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WBP11P3 →	-0.472	-0.542	.003	.003	3	3
OV	RANP2 →	-1.413	-0.545	.001	.002	3	3
UCEC	ZNF33BP1 →	-0.767	-0.895	<.001	<.001	3	3
GBM	FGD5 →	+0.346	+0.452	.003	.003	3	3
GBM	ARPC5 →	+0.386	+0.595	<.001	.005	3	3
OV	CCDC91 →	-0.566	-0.851	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014856 vs WBP11P3 — OV

Explore this scatter interactively →