Response to inactivity

Across TCGA patient cohorts, RNA activity of the Response to inactivity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR199B, PREPL, and EFHC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to inactivity activity versus MIR199B in UCEC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR199B →	+0.474	+0.399	.005	.006	3	4
GBM	PREPL →	+0.255	+0.163	.004	.004	3	4
GBM	EFHC1 →	+0.495	+0.350	<.001	<.001	3	4
BRCA	NMRAL2P →	+0.262	+0.486	<.001	<.001	3	3
OV	TTC32 →	+0.679	+0.693	.005	.006	3	3
OV	AKT3-IT1 →	+0.108	+0.797	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014854 vs MIR199B — UCEC

Explore this scatter interactively →