Response to inactivity

Across TCGA cell cohorts, RNA activity of the Response to inactivity pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, CREG1, and IRAK1BP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to inactivity activity versus CAT in SOFT_TISSUE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CAT →	+1.739	+1.601	<.001	.004	3	6
BLOOD_Leukemia	CREG1 →	+2.103	+0.403	<.001	<.001	3	4
LUNG_SCLC	IRAK1BP1 →	-0.818	-0.897	.001	.002	3	4
LUNG_SCLC	SLC35G2 →	-1.669	-1.231	<.001	<.001	3	4
LUNG_SCLC	LRRC34 →	-2.803	-1.533	<.001	<.001	3	4
LUNG_SCLC	ACAT1 →	+0.839	+0.906	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014854 vs CAT — SOFT_TISSUE

Explore this scatter interactively →