Response to muscle activity

Across TCGA patient cohorts, RNA activity of the Response to muscle activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2_S928, CRTAP, and SULF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle activity activity versus RPRD2_S928 in GBM (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPRD2_S928 →	-0.472	-0.071	<.001	<.001	3	6
GBM	CRTAP →	+0.429	+0.071	<.001	<.001	3	6
OV	SULF1 →	+1.190	+0.057	<.001	<.001	3	5
LUAD	TP53BP2_S582 →	+0.409	+0.067	.001	.001	3	5
GBM	BMP1 →	+0.516	+0.052	<.001	<.001	3	5
LUAD	EEF2_S502 →	+0.674	+0.071	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014850 vs RPRD2_S928 — GBM

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