Response to muscle activity

Across TCGA patient cohorts, RNA activity of the Response to muscle activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN5, KANK3, and ASPA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle activity activity versus CLDN5 in CCRCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLDN5 →	+0.900	+0.543	<.001	<.001	3	8
CCRCC	KANK3 →	+0.987	+0.634	<.001	<.001	3	7
OV	ASPA →	+0.551	+0.516	<.001	.002	3	6
HNSC	FHL1 →	+1.397	+0.347	<.001	<.001	3	6
CCRCC	RAMP2 →	+1.122	+0.785	<.001	<.001	3	6
CCRCC	HSPA12B →	+0.902	+0.759	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014850 vs CLDN5 — CCRCC

Explore this scatter interactively →