Response to muscle activity

Across TCGA cell cohorts, RNA activity of the Response to muscle activity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, KCNJ11, and ABLIM3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle activity activity versus ITGB1 in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGB1 →	+1.630	+0.333	.001	<.001	3	8
BONE	KCNJ11 →	-1.204	-0.371	.002	.004	3	8
BONE	ABLIM3 →	+4.052	+0.468	.008	.001	3	7
OVARY	SNX27 →	-0.951	-0.294	.002	.002	3	6
STOMACH	PASK →	-1.373	-0.269	.009	.003	2	7
STOMACH	PIK3C2B →	-2.161	-0.252	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014850 vs ITGB1 — BREAST

Explore this scatter interactively →