Urinary tract smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Urinary tract smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, GFPT1, and MPRIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urinary tract smooth muscle contraction activity versus SGCD in HNSC (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SGCD →	+0.863	+0.064	<.001	.001	3	5
CCRCC	GFPT1 →	-0.274	-0.045	<.001	<.001	3	5
CCRCC	MPRIP →	+0.302	+0.058	<.001	.002	3	5
CCRCC	NOP2 →	-0.395	-0.068	<.001	<.001	3	5
CCRCC	ESF1_S153 →	-0.526	-0.071	<.001	<.001	3	5
CCRCC	SORBS3 →	+0.490	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014848 vs SGCD — HNSC

Explore this scatter interactively →