Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

pathway activity — cross-omics
GO:0014834Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIA1, P3H3, and SDF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCATIA1 →+0.314+0.092<.001<.00137
OVP3H3 →+0.750+0.088<.001<.00137
LSCCSDF2 →+0.521+0.172<.001<.00137
HNSCFZD7 →+0.786+0.137<.001<.00137
LUADVIPAS39 →-0.177-0.071<.001.00237
HNSCARHGEF37 →-0.310-0.084<.001.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration