Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

pathway activity — cross-omics
GO:0014834Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPA, PRC1, and CDKN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADCENPA →+1.451+0.449<.001<.00138
LSCCPRC1 →+0.440+1.081<.001<.00138
LUADCDKN3 →+1.543+0.781<.001<.00137
LUADNEK2 →+1.480+0.545<.001<.00137
LUADKIF23 →+1.408+0.607<.001<.00137
LUADKNL1 →+0.986+0.515<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration