Urinary bladder smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Urinary bladder smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1, HCLS1, and ARHGEF6_S640, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urinary bladder smooth muscle contraction activity versus RTN1 in OV (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RTN1 →	-0.562	-0.099	<.001	<.001	3	4
OV	HCLS1 →	-0.445	-0.080	.001	.003	3	4
OV	ARHGEF6_S640 →	-0.627	-0.050	.005	.008	3	4
UCEC	SCRIB_S853 →	+0.755	+0.102	<.001	<.001	3	4
UCEC	DOCK11 →	-0.398	-0.094	.004	<.001	2	5
UCEC	LIMK2 →	+0.379	+0.084	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014832 vs RTN1 — OV

Explore this scatter interactively →