Urinary bladder smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Urinary bladder smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4A1P6, CDKN3, and RAD51AP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urinary bladder smooth muscle contraction activity versus EIF4A1P6 in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EIF4A1P6 →	-0.076	-0.472	.005	.005	3	3
UCEC	CDKN3 →	-0.549	-0.615	.003	<.001	3	3
UCEC	RAD51AP1 →	-0.578	-0.547	.003	<.001	3	3
UCEC	DLGAP5 →	-0.684	-0.541	.007	<.001	3	3
UCEC	CCDC150 →	-0.628	-0.630	.006	.001	3	3
UCEC	SPC25 →	-0.523	-0.457	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014832 vs EIF4A1P6 — LSCC

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