Urinary bladder smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Urinary bladder smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP2B4_S328, SLC3A2, and TMPO_S184, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urinary bladder smooth muscle contraction activity versus ATP2B4_S328 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP2B4_S328 →	+0.967	+0.777	<.001	<.001	3	6
BRCA	SLC3A2 →	+0.434	+0.273	<.001	.002	3	3
OV	TMPO_S184 →	-1.087	-0.680	<.001	<.001	3	3
GBM	ZC3H13_S325 →	-0.569	-0.636	.004	<.001	3	3
GBM	CPSF3 →	-0.152	-0.611	<.001	<.001	3	3
OV	SPTBN1_T2195 →	+0.956	+0.743	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014832 vs ATP2B4_S328 — UCEC

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