Urinary bladder smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Urinary bladder smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LBHD1, EFTUD2, and SERPINF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LBHD1 grouped by Urinary bladder smooth muscle contraction-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LBHD1 →	-1.107	-1.060	<.001	.001	3	4
SKIN	EFTUD2 →	-0.529	-0.786	.001	.009	3	3
SKIN	SERPINF1 →	-3.023	-0.820	<.001	.003	3	3
BREAST	CYP2D6 →	+0.864	+0.645	.003	.008	3	3
BLOOD_Lymphoma	CSE1L →	-1.040	-0.383	.006	.005	3	3
UPPER_AERODIGESTIVE_TRACT	IFT22 →	-1.396	-1.016	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LBHD1 by Urinary bladder smooth muscle contraction activity — KIDNEY

Explore this box plot interactively →