Gastro-intestinal system smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Gastro-intestinal system smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENTPD1, TLN1, and STAB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gastro-intestinal system smooth muscle contraction activity versus ENTPD1 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ENTPD1 →	+0.548	+0.076	<.001	<.001	3	8
COAD	TLN1 →	+0.427	+0.061	<.001	<.001	3	8
GBM	STAB1 →	+0.530	+0.098	<.001	<.001	3	7
GBM	GIMAP7 →	+0.593	+0.103	<.001	<.001	3	7
LSCC	RCSD1 →	+0.476	+0.092	<.001	<.001	3	7
COAD	RSU1 →	+0.364	+0.045	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014831 vs ENTPD1 — OV

Explore this scatter interactively →