Gastro-intestinal system smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Gastro-intestinal system smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, INHBA-AS1, and F3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gastro-intestinal system smooth muscle contraction activity versus INHBA in COAD (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INHBA →	+1.270	+0.853	<.001	<.001	3	6
COAD	INHBA-AS1 →	+0.215	+0.791	<.001	<.001	3	6
CCRCC	F3 →	+1.230	+0.882	.003	<.001	3	5
OV	MGP →	+1.240	+0.604	.002	.002	3	5
OV	DSE →	+0.529	+0.547	.002	.001	2	6
OV	RUNX2 →	+1.174	+0.635	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014831 vs INHBA — COAD

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