Vascular associated smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Vascular associated smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIM1, EDN1, and CRYBG3, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle contraction activity versus CRIM1 in THYM (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	CRIM1 →	+1.839	+0.051	<.001	<.001	3	30
DLBC	EDN1 →	+1.785	+0.054	<.001	<.001	3	30
DLBC	CRYBG3 →	+1.164	+0.060	<.001	<.001	3	30
KICH	DOCK9 →	+1.231	+0.038	<.001	.001	2	31
THYM	NFAT5 →	+1.797	+0.054	<.001	<.001	3	30
UVM	PIK3C2A →	+1.747	+0.036	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014829 vs CRIM1 — THYM

Explore this scatter interactively →