Vascular associated smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Vascular associated smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LUM, ARHGEF17, and PRKG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle contraction activity versus LUM in OV (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LUM →	+0.814	+0.044	<.001	<.001	3	8
UCEC	ARHGEF17 →	+0.334	+0.068	<.001	.002	3	8
OV	PRKG1 →	+0.664	+0.063	<.001	<.001	3	8
LSCC	NOP16 →	-0.386	-0.079	<.001	<.001	3	8
GBM	SF3B1 →	-0.263	-0.099	<.001	<.001	3	8
GBM	HNMT →	+0.675	+0.084	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014829 vs LUM — OV

Explore this scatter interactively →