Intestine smooth muscle contraction

pathway activity — cross-omics
GO:0014827Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Intestine smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WWTR1_S296, RHBDF2, and SEC61B_S17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADWWTR1_S296 →-1.222-0.312<.001.00133
OVRHBDF2 →+1.136+1.385<.001<.00132
OVSEC61B_S17 →+1.414+1.144.001<.00132
OVSMARCA2_S1377 →+1.241+1.077.003.00132
OVBAIAP2_S325 →+0.887+1.156<.001<.00132
OVDCDC2_S270 →+1.560+1.060<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration