Intestine smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Intestine smooth muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GHSR, PTGER3, and TACR2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GHSR grouped by Intestine smooth muscle contraction-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GHSR →	-0.198	-1.222	<.001	<.001	3	8
LUNG_NSCLC_LUAD	PTGER3 →	-0.310	-0.946	<.001	<.001	3	7
OVARY	TACR2 →	-0.234	-1.225	<.001	<.001	3	6
KIDNEY	KIT →	-0.192	-1.013	.005	.002	3	5
BREAST	PARP1 →	-0.192	-0.951	<.001	<.001	3	4
STOMACH	CDC42 →	+0.428	+0.862	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GHSR by Intestine smooth muscle contraction activity — CNS

Explore this box plot interactively →