Intestine smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Intestine smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSCC1, CTSS, and RNASET2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DSCC1 grouped by Intestine smooth muscle contraction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DSCC1 →	+0.963	+0.580	.001	.004	3	4
CNS	CTSS →	-1.668	-0.776	.005	.008	3	4
KIDNEY	RNASET2 →	-2.065	-1.269	.004	.001	3	4
LUNG_NSCLC_LUAD	RPL5 →	+0.529	+0.517	.001	.008	2	4
BLOOD_Myeloma	DPH5 →	+0.975	+0.375	.002	<.001	3	3
BLOOD_Leukemia	ATF6 →	+0.723	+0.212	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DSCC1 by Intestine smooth muscle contraction activity — BREAST

Explore this box plot interactively →