Intestine smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Intestine smooth muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF2, BCL2L1, and DCAF8L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF2 grouped by Intestine smooth muscle contraction-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ARHGEF2 →	-0.195	-0.229	.009	.007	3	3
BLOOD_Leukemia	BCL2L1 →	+0.875	+1.655	.005	<.001	2	4
LUNG_NSCLC_LUSC	DCAF8L1 →	-0.294	-0.230	.001	.002	3	3
LUNG_NSCLC_LUSC	NOX1 →	-0.135	-0.238	.006	<.001	3	3
KIDNEY	KLF4 →	-0.252	-0.146	.001	.002	3	3
KIDNEY	NWD2 →	+0.126	+0.215	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF2 by Intestine smooth muscle contraction activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →