Phasic smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Phasic smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOJ, HRC, and TBX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phasic smooth muscle contraction activity versus RHOJ in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RHOJ →	+0.533	+0.410	<.001	<.001	3	6
CCRCC	HRC →	+0.686	+0.348	<.001	.001	3	5
CCRCC	TBX2 →	+0.796	+0.422	<.001	<.001	3	5
GBM	EDNRB →	+1.437	+0.618	<.001	<.001	3	5
UCEC	MOCS1 →	+0.716	+0.498	.004	.007	3	4
CCRCC	COX4I2 →	+1.082	+0.458	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014821 vs RHOJ — CCRCC

Explore this scatter interactively →