Regulation of skeletal muscle contraction

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DMD, RNF213, and FERMT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle contraction activity versus DMD in HNSC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DMD →	+1.085	+0.118	<.001	<.001	3	8
BRCA	RNF213 →	-0.370	-0.027	<.001	.007	3	7
BRCA	FERMT2 →	+0.582	+0.039	<.001	<.001	2	8
BRCA	DDX21_S89 →	-0.835	-0.038	.005	.002	3	7
BRCA	HSPG2 →	+0.519	+0.029	<.001	.005	3	7
HNSC	PDLIM5 →	+0.488	+0.118	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014819 vs DMD — HNSC

Explore this scatter interactively →