Regulation of skeletal muscle contraction

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP3, CALHM5, and CNRIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle contraction activity versus TIMP3 in UCEC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMP3 →	+1.028	+0.705	.001	.001	3	7
BRCA	CALHM5 →	+0.682	+0.743	<.001	.003	2	7
LSCC	CNRIP1 →	+0.400	+0.539	<.001	.001	3	6
PDAC	COL8A1 →	+0.826	+0.545	<.001	<.001	3	6
HNSC	HNMT →	+0.708	+0.921	.005	.001	3	6
BRCA	DACT1 →	+0.697	+0.457	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014819 vs TIMP3 — UCEC

Explore this scatter interactively →