Regulation of skeletal muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1C, CCDC57, and PARD6B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORO1C grouped by Regulation of skeletal muscle contraction-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CORO1C →	-1.597	-1.698	.009	.009	3	6
OVARY	CCDC57 →	+1.132	+0.999	.002	.002	3	5
KIDNEY	PARD6B →	+1.475	+1.117	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	ARHGAP22 →	-1.520	-1.356	.009	.001	3	5
CNS	FSTL3 →	-2.172	-0.836	<.001	.004	3	4
LUNG_SCLC	BDKRB2 →	-2.659	-1.395	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORO1C by Regulation of skeletal muscle contraction activity — BONE

Explore this box plot interactively →