Regulation of skeletal muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF837, SOD1, and ADPRM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle contraction activity versus ZNF837 in LUNG_NSCLC_LUSC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF837 →	+0.536	+0.328	.009	.002	3	5
BONE	SOD1 →	-0.722	-0.366	.003	.002	3	4
SOFT_TISSUE	ADPRM →	+0.753	+0.241	.009	.003	3	4
LUNG_NSCLC_LUSC	RAE1 →	+0.832	+0.412	.008	<.001	3	4
BONE	MRPL18 →	-0.672	-0.500	.002	<.001	3	4
BLOOD_Leukemia	MAD2L2 →	+1.311	+0.272	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014819 vs ZNF837 — LUNG_NSCLC_LUSC

Explore this scatter interactively →