Skeletal muscle satellite cell differentiation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle satellite cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYLK_S1208, TGFB1, and ZYX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle satellite cell differentiation activity versus MYLK_S1208 in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MYLK_S1208 →	-0.549	-0.079	.003	.002	3	6
LUAD	TGFB1 →	-0.317	-0.114	<.001	<.001	3	6
UCEC	ZYX →	-0.418	-0.094	<.001	<.001	3	6
LUAD	CDC42BPA →	-0.459	-0.071	.002	.008	3	6
HNSC	NIPSNAP1 →	+0.410	+0.098	<.001	.001	3	5
LUAD	TGFB1I1_S164 →	-0.545	-0.077	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014816 vs MYLK_S1208 — OV

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