Skeletal muscle satellite cell differentiation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle satellite cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIX4, KLF5, and CDON, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIX4 grouped by Skeletal muscle satellite cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SIX4 →	-0.324	-0.961	.001	.002	3	10
PANCREAS	KLF5 →	-0.571	-1.428	<.001	<.001	3	7
BREAST	CDON →	-0.238	-1.027	<.001	<.001	3	6
BLOOD_Leukemia	MSTN →	-0.202	-1.107	<.001	<.001	3	5
OESOPHAGUS	PKHD1L1 →	-0.164	-2.198	.006	<.001	3	5
CNS	CCL8 →	-0.127	-1.014	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIX4 by Skeletal muscle satellite cell differentiation activity — OVARY

Explore this box plot interactively →