Skeletal muscle satellite cell differentiation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle satellite cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHBDD3, ZCRB1, and ARL6IP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHBDD3 grouped by Skeletal muscle satellite cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RHBDD3 →	-0.340	-2.430	.009	<.001	3	4
SOFT_TISSUE	ZCRB1 →	+0.311	+1.362	.007	.004	3	3
LUNG_NSCLC_LUAD	ARL6IP5 →	-0.093	-0.088	.006	<.001	3	3
LUNG_NSCLC_LUAD	DCTN1 →	-0.276	-0.096	.005	.009	3	3
LUNG_NSCLC_LUSC	NEK2 →	+0.292	+0.211	.004	.005	3	3
BONE	TMEM44 →	+0.178	+2.163	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHBDD3 by Skeletal muscle satellite cell differentiation activity — BONE

Explore this box plot interactively →