Skeletal muscle satellite cell differentiation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle satellite cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLK2, UHRF1, and ALS2CL, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle satellite cell differentiation activity versus MYLK2 in BLOOD_Leukemia (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYLK2 →	+1.045	+0.351	<.001	.001	3	13
BLOOD_Leukemia	UHRF1 →	+1.751	+0.234	<.001	.008	1	10
UPPER_AERODIGESTIVE_TRACT	ALS2CL →	-1.607	-0.136	.003	.008	3	7
BONE	PAQR7 →	-1.560	-1.420	<.001	<.001	3	7
BLOOD_Lymphoma	S100A14 →	-0.503	-0.075	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	ITPKC →	-0.950	-0.160	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014816 vs MYLK2 — BLOOD_Leukemia

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