Regulation of somitogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of somitogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLINT1, DTX3L, and SEC24A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of somitogenesis activity versus CLINT1 in OV (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLINT1 →	-0.275	-0.109	.003	.001	3	6
OV	DTX3L →	-0.718	-0.117	<.001	<.001	3	6
CCRCC	SEC24A →	-0.280	-0.084	<.001	.003	3	5
CCRCC	TMF1 →	-0.231	-0.094	<.001	<.001	3	5
CCRCC	COPB1 →	-0.166	-0.107	<.001	<.001	3	5
GBM	ARCN1 →	-0.217	-0.224	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014807 vs CLINT1 — OV

Explore this scatter interactively →