Smooth muscle adaptation

Across TCGA patient cohorts, RNA activity of the Smooth muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2_T593, TNFAIP8, and AMPD3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle adaptation activity versus THEMIS2_T593 in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THEMIS2_T593 →	+0.618	+0.063	<.001	<.001	3	9
GBM	TNFAIP8 →	+0.743	+0.151	<.001	<.001	3	9
GBM	AMPD3 →	+0.695	+0.181	<.001	<.001	3	9
COAD	ITGAM →	+0.831	+0.106	<.001	<.001	3	9
GBM	APBB1IP →	+0.557	+0.149	<.001	<.001	3	9
OV	PRAM1 →	+0.796	+0.092	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014805 vs THEMIS2_T593 — BRCA

Explore this scatter interactively →