Smooth muscle adaptation

Across TCGA patient cohorts, RNA activity of the Smooth muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR-AS1, TLR8, and HRH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle adaptation activity versus CFLAR-AS1 in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CFLAR-AS1 →	+0.437	+0.156	.006	.008	2	6
BRCA	TLR8 →	+0.846	+0.638	<.001	.001	3	5
LSCC	HRH2 →	+0.844	+0.310	<.001	<.001	3	5
LSCC	RIN3 →	+0.532	+0.285	<.001	<.001	3	5
BRCA	PARP15 →	+0.776	+0.634	.001	.002	3	5
BRCA	IL32 →	+0.672	+0.395	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014805 vs CFLAR-AS1 — LUAD

Explore this scatter interactively →