Smooth muscle adaptation

Across TCGA cell cohorts, RNA activity of the Smooth muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNC, DLEC1, and PPP2R3C, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle adaptation activity versus TNC in KIDNEY (Pearson r = 1.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TNC →	+4.885	+1.585	.001	.008	1	2
KIDNEY	DLEC1 →	-0.180	-1.585	.001	.008	1	2
KIDNEY	PPP2R3C →	+0.799	+1.585	.009	.008	1	2
KIDNEY	CNIH1 →	+0.759	+1.585	.004	.008	1	2
KIDNEY	SGIP1 →	+3.219	+1.585	<.001	.008	1	2
KIDNEY	TTC32 →	-0.695	-1.585	.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014805 vs TNC — KIDNEY

Explore this scatter interactively →