Negative regulation of muscle adaptation

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMAD3, RRBP1_T275, and KANK2_S540, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle adaptation activity versus SMAD3 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMAD3 →	+0.476	+0.100	<.001	.001	3	6
CCRCC	RRBP1_T275 →	-0.742	-0.055	<.001	<.001	3	6
BRCA	KANK2_S540 →	+0.600	+0.065	<.001	<.001	3	6
UCEC	LMNA →	+0.596	+0.076	<.001	<.001	3	6
CCRCC	LMNB2 →	+0.313	+0.098	<.001	<.001	3	6
HNSC	EEF2_T435 →	-0.565	-0.102	.003	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014745 vs SMAD3 — HNSC

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