Negative regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTL8C, OLFML2B, and LRPPRC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTL8C grouped by Negative regulation of muscle adaptation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RTL8C →	+1.538	+1.765	<.001	<.001	3	6
SKIN	OLFML2B →	+2.093	+1.152	<.001	.001	3	5
LUNG_SCLC	LRPPRC →	-0.937	-1.533	.007	.003	3	4
BLOOD_Leukemia	TIMP1 →	+1.781	+0.964	.004	<.001	3	4
BLOOD_Leukemia	LRRC1 →	-1.254	-0.812	<.001	.004	3	4
URINARY_TRACT	IGFBP7 →	+5.656	+1.759	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTL8C by Negative regulation of muscle adaptation activity — LUNG_SCLC

Explore this box plot interactively →