Negative regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPFFR1, ZCCHC2, and NONO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle adaptation activity versus NPFFR1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NPFFR1 →	+0.092	+0.189	.002	.002	3	4
LUNG_NSCLC_LUSC	ZCCHC2 →	-1.277	-0.065	.003	.003	3	4
LUNG_NSCLC_LUSC	NONO →	-0.833	-0.065	.002	.003	3	4
PANCREAS	ZEB1 →	-1.256	-0.150	.006	.002	3	4
KIDNEY	NBPF9 →	-0.664	-0.267	.002	.009	3	4
BLOOD_Leukemia	GNAI2 →	-0.962	-1.119	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014745 vs NPFFR1 — UPPER_AERODIGESTIVE_TRACT

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