Negative regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOL3, SMAD3, and EEF2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle adaptation activity versus NOL3 in OESOPHAGUS (Pearson r = -0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NOL3 →	-1.937	-0.258	.002	<.001	3	9
LIVER	SMAD3 →	-1.270	-0.173	.005	.007	3	8
URINARY_TRACT	EEF2 →	-2.392	-0.252	<.001	<.001	3	7
SOFT_TISSUE	ATP2B4 →	-1.586	-0.176	.004	.001	3	7
URINARY_TRACT	HINT1 →	-2.709	-0.223	.003	.005	3	6
URINARY_TRACT	DYNC1H1 →	-1.786	-0.247	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014745 vs NOL3 — OESOPHAGUS

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