Positive regulation of muscle adaptation

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC14L2, SON, and TANK_S178, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle adaptation activity versus SEC14L2 in UCEC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC14L2 →	-0.504	-0.117	<.001	<.001	3	4
LUAD	SON →	+0.116	+0.059	.002	.004	3	4
HNSC	TANK_S178 →	-0.329	-0.075	.001	.001	3	4
HNSC	PGAM1 →	-0.315	-0.080	<.001	<.001	3	4
LSCC	PKM →	-0.291	-0.092	<.001	<.001	3	4
PDAC	PES1 →	+0.250	+0.081	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014744 vs SEC14L2 — UCEC

Explore this scatter interactively →