Positive regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF2BP2, BST2, and AKR1E2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF2BP2 grouped by Positive regulation of muscle adaptation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IRF2BP2 →	-0.850	-0.888	.007	.006	3	4
UPPER_AERODIGESTIVE_TRACT	BST2 →	+2.903	+1.108	.001	.004	3	3
BONE	AKR1E2 →	+2.345	+0.549	.003	.007	2	4
LUNG_NSCLC_LUSC	PTPRS →	-1.628	-1.245	.006	.003	3	3
LUNG_NSCLC_LUSC	DVL3 →	-1.026	-1.269	<.001	.002	3	3
LUNG_NSCLC_LUSC	PLXDC1 →	-0.606	-1.149	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF2BP2 by Positive regulation of muscle adaptation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →