Positive regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle adaptation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOOK1, RPS3A, and KIF4B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOOK1 grouped by Positive regulation of muscle adaptation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HOOK1 →	-0.153	-1.146	.005	.005	3	4
SOFT_TISSUE	RPS3A →	-0.346	-1.684	.002	<.001	3	4
LARGE_INTESTINE	KIF4B →	+0.170	+0.784	.002	.009	3	3
PANCREAS	PRDX4 →	+0.266	+0.141	.003	.002	2	4
SOFT_TISSUE	CNKSR2 →	+0.253	+1.696	<.001	<.001	3	3
OVARY	TBC1D9 →	-0.169	-0.856	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOOK1 by Positive regulation of muscle adaptation activity — SKIN

Explore this box plot interactively →