Positive regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO3, PDSS2, and NME1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle adaptation activity versus FOXO3 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FOXO3 →	+1.364	+0.668	<.001	<.001	3	20
BREAST	PDSS2 →	+0.958	+0.983	<.001	.001	3	9
SKIN	NME1 →	-0.855	-1.031	<.001	<.001	3	9
LARGE_INTESTINE	FUT3 →	+2.103	+0.461	.003	.008	3	9
SKIN	ATP8B1 →	+1.206	+0.808	.001	.001	3	9
LUNG_NSCLC_LUAD	CREM →	-0.972	-0.893	.003	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014744 vs FOXO3 — STOMACH

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